Inactivation of rifampin by Nocardia brasiliensis
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منابع مشابه
Inactivation of rifampin by Nocardia brasiliensis.
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gr...
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The reported case is of primary pulmonary nocardiosis, caused by Nocardia brasiliensis, in a immunocompromised patient, which ended fatally despite appropriate treatment. The partially acid fast filamentous bacterium was predominant on direct examination of the sputum. It was cultured on blood agar, MacConkey agar and by paraffin baiting technique. The bacterium was resistant to cotrimoxazole, ...
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1. Polasky, N., Polasky, S., Magenheim, H. & Abrams, N.R. Giant cell arteritis. Review and report of a case. JAMA 1965, 191: 341-343. 2. Nehra, P.C., Ramus, D.M. & Peterson, J. Giant-cell arteritis of the uterus with associated temporal arteritis: a case report. Obstet Gynecol 1990, 76: 935-938. 3. Padwell, A. Isolated arteritis of the uterine cervix. Three cases report. Br J Obstet Gynaecol 19...
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Rifampin (RIF) is a first-line drug used for the treatment of tuberculosis and other bacterial infections. Various RIF resistance mechanisms have been reported, and recently an RIF-inactivation enzyme, RIF phosphotransferase (RPH), was reported to phosphorylate RIF at its C21 hydroxyl at the cost of ATP. However, the underlying molecular mechanism remained unknown. Here, we solve the structures...
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Since the discovery of erythromycin A (1; Fig. 1)1} more than 25 biosynthetic representatives of this family of 14-membered macrolide antibiotics have been reported. Most of erythromycins are produced by the genera Saccharopolyspora and Streptomyces but few by Nocardia strains2). Erythromycin E (2; Fig. 1) is distinguishable from all the other known macrolide antibiotics and other microbial met...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.6.1313